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Only two of Mary's siblings survived: her older brother John Jr.

Her parents worked for Samuel Salt, a barrister in London, and the family lived above Salt in his home at 2 Crown Office Row in the Inner Temple. Mary Lamb was born in London on 3 December 1764, the third of seven children of John and Elizabeth Lamb. She and Charles presided over a literary circle in London that included the poets William Wordsworth and Samuel Taylor Coleridge, among others. She was confined to mental facilities for most of her remaining life. Mary suffered from mental illness, and in 1796, aged 31, she stabbed her mother to death during a mental breakdown.

She is best known for the collaboration with her brother Charles on the collection Tales from Shakespeare (1807). Mary Anne Lamb (3 December 1764 – ) was an English writer.